Research experience @ iit madras
Project Title | Principal Investigator | University | Project Description | Journal/Technical Conference |
---|---|---|---|---|
AFM observation of spatio-temporal control of Protein-DNA interaction | Professor Dr. Hiroshi Sugiyama, and Associate Professor Dr. Masayuki Endo | ICeMS, Kyoto University, Kyoto, Japan | The research objective was to spatio-temporally control the formation of Protein-DNA Complex using visible light by visualization under the High-speed Atomic Force Microscopy. Along with that, I computationally modeled the Protein-DNA complex dynamics by applying principles borrowed from classical mechanics, and state-space systems. | In the process of writing a manuscript (research paper)Awarded the first position at the IIT Research Expo, Jan, 2015 |
Synaptic Vesicles dynamics using DNA Nanostructures | Dr. Yamuna Krishnan | National Center for Biological Sciences (NCBS), Bangalore, India | The objective was to well characterize a DNA binding protein to be expressed in Synaptic vesicles to track physiological changes like pH, Chloride concentration inside these vesicles. I also learned to work with C-elegans model organism | -- |
pH Mediated DNA Hopping | Dr. N Manoj | IIT Madras, Chennai, India | Designed a Molecular Robot responsive to pH of the solution, and verified the formation of structure in-silico using NUPACK (online software) and DNA Native PAGE | Presented Poster at PAN-IIT Research Expo, Jan 2014 |
Alteration of pH sensitive regime of I-switch | Dr. Yamuna Krishnan | National Center for Biological Sciences (NCBS), Bangalore, India | Worked on varying the pH sensitive regime of DNA, LNA switches by implementing modifications in the Cytosine residues comprising the i-motif. Characterization of the change was studied by extensive FRET measurements | -- |
Myoelectric Prosthetic Arm | Center for InnovationMentor: Preejith SP, M.S scholar from Prof Mohan shankar's Lab, IIT M | IIT Madras, Chennai, India | Succeeded in controlling simple electrical devices using Electromyograph signals. The EMG signals were processed in MATLAB and LabView. Feature extraction was performed was performed to identify distinct muscular movements. | Center for Innovation - Open Day (presented to director, professors and alumni of IIT Madras) |
DNA based Logic Gates "Biological Circuits" | Dr. N Manoj - Faculty incharge | IIT Madras, Chennai, India | Worked on CadNano-2 to design DNA Nano-devices that can get activated by the output received from DNA logic gates | Biospectra. Anna University Paper Presentation (1st Place) |